Immune complex-induced apoptosis and concurrent immune complex clearance are anti-inflammatory neutrophil functions
نویسندگان
چکیده
منابع مشابه
Immune Complex Nephritis Induced
Recent experimental studies have shown that the local b inding of circulating ant ibody with antigens existing or planted within the glomerulus can result in damage to this structure (1-6). In particular, chemically cationized proteins are able to bind to the glomerular basement membrane (GBM), act as a planted antigen, and induce in situ immune complex formation accompanied by marked proteinur...
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19. Lenk, R. P., Maize], J. V. & Crouch, R. J. ( 1 982) Eur. J. Biochem. 121,475-482 Habets, W. J., Moet, M., van de Pas, J. & Van Venrooij, W. J. (1985) in Protides of the Biological Fluids (Peeters, H., ed.), vol. 33, pp. 199-204 Baboonian, C., Venables, P. J. W., Booth, J., Williams, D. G., Roffe, L. M. & Maini, R N. (1989) Clin. Exp. Immunol. 78,454-459 Mathews, M. B. & Bernstein, R. M. (19...
متن کاملextreme thrombocytosis presenting in anti-neutrophil cytoplasmic autoantibodies-associated crescentic glomerulonephritis with immune complex deposits: a case report
conclusions the diagnosis of thrombocytosis is not easy in all cases. the coexistence of anca and the immune complex in cgn may cause a severe inflammatory state, leading to extreme rt. the roles that the immune complex and anca play on the effect of the platelet count and function in cgn need further research. introduction we describe a female patient with extreme reactive thrombocytosis (rt) ...
متن کامل894 Immune Complex - Induced Monocyte Procoagulant Response
The coagulation pathways not only serve hemostatic functions but also appear to be important participants in inflammatory responses, including certain immunologically induced tissue lesions. Local deposition of fibrin is characteristically an early and active process in the immunologic lesions of experimental allergic encephalomyelitis (1, 2), acute proliferative glomerulonephritis (3), delayed...
متن کاملNeutrophil functional responses depend on immune complex valency.
Ligand-induced cross-linking of Fc gamma receptors (Fc gamma R) on neutrophils plays a significant role in their stimulation, shown here by contrasting the responses induced by low valency immune complexes (LICs) and high valency immune complexes (HICs) and by cross-linking LICs in situ (L/Ab) after their addition to the cells. Multiparameter flow cytometry was used to measure immune complex (I...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2021
ISSN: 2041-4889
DOI: 10.1038/s41419-021-03528-8